Paddy, 48, made the announcement on Saturday lunchtime, just hours before kick-off this evening.
Speaking to his 1.9 million followers on Instagram, the new Question of Sport host announced he’d had to quit the line-up.
The presenter posted a selection of snaps of him preparing for the event, as well as one displaying the injury he had sustained.
Paddy shared: ‘Gutted! For the first time ever I’m having to pull out of @socceraid due to injury.
‘Tore my lateral meniscus and it’s not something that can be sorted with the magic sponge.
‘Good luck to both teams today and if you’ve got tickets you’re in for a great day for a great cause.’
Friends and fans of the Question of Sport and Top Gear star quickly responded to the update to give out their well wishes.
Comedian Joel Dommett, who will now be taking Paddy’s place in goal, commented: ‘Thinking of you buddy! I’ll do you proud!’
It comes after Paddy appeared on The One Show on Friday night, telling host Ronan Keating he had been ‘nursing a few injuries’ ahead of preparation for the game.
He said: ‘I’m a goalkeeper this year. I’ve had a busy year and I’ve not been able to train as much.
‘I picked up a little injury on my foot so I said to David Seaman, “I’ll go in the net. That’ll be easy.” It turns out that it isn’t.’
But he added: ‘I’ve been involved in Soccer Aid for a long, long time. It raises so much money for Unicef.’
On Friday night, another famous face had to drop out of the line-up of the charity fixture unexpectedly.
Capital Radio DJ Roman Kemp revealed he had tested positive for Covid, meaning he could no longer take part.
Taking to Twitter, he said: ‘I’m absolutely gutted. I’ve had a positive test come through so I won’t be playing at @SoccerAid tomorrow night.
‘I’ll be cheering from a sofa and hope that everyone donates as much as they can for the cause. Come on Soccer Aid World XI FC!’
Soccer Aid is an annual football match which sees celebrities and football legends from England and the Rest of the World take each other on in order to raise money for Unicef.
Soccer Aid airs tonight from 6:30pm on ITV.
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